Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized - Takeaways - MDSpire

Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized

  • By

  • Mohamed Ridha

  • Raed Hailat

  • Robert Stanton

  • Alexander E. Merkler

  • Mitchell S. V. Elkind

  • W. T. Longstreth

  • David L. Tirschwell

  • Richard A. Kronmal

  • Yousef Hannawi

  • Hooman Kamel

  • James Burke

  • Daniel Woo

  • June 1, 2026

  • 0 min

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  • 1

    The ARCADIA trial examined the effects of apixaban versus aspirin on stroke recurrence in patients with cryptogenic stroke and atrial cardiopathy.

  • 2

    Eligible participants were aged 45 or older, had a recent cryptogenic ischemic stroke, and evidence of atrial cardiopathy.

  • 3

    Hypertension with high-risk features was defined as a systolic blood pressure of 160 mm Hg or greater or cardiac evidence of hypertension-mediated organ damage.

  • 4

    Patients with uncontrolled hypertension were eligible but randomization was delayed until at least 2 weeks after the index stroke.

  • 5

    The study aimed to explore whether hypertension risk stratification could identify differences in antithrombotic response in cryptogenic stroke patients.

Original Source(s)

Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized

  • by Mohamed Ridha, Raed Hailat, Robert Stanton, Alexander E. Merkler, Mitchell S. V. Elkind, W. T. Longstreth, David L. Tirschwell, Richard A. Kronmal, Yousef Hannawi, Hooman Kamel, James Burke, Daniel Woo

  • June 1, 2026

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