Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain—a multicenter pragmatic randomized controlled trial (RESET) - Takeaways - MDSpire

Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain—a multicenter pragmatic randomized controlled trial (RESET)

  • By

  • Zachary L McCormick

  • Denise D Lester

  • Michael J DePalma

  • Christopher A Gilmore

  • Sean Li

  • Jessica B Jameson

  • Mehul J Desai

  • Tristan E Weaver

  • Shivanand P Lad

  • Scott J Davidoff

  • Drew M Trainor

  • Kasra Amirdelfan

  • Mitchell P Engle

  • Timothy R Deer

  • Thomas S Lee

  • Francesco Vetri

  • Meenakshi Bindal

  • Melissa A Tornero-Bold

  • Morad N Nasseri

  • Steven P Cohen

  • William H Clark

  • Meredith J McGee

  • Joseph W Boggs

  • October 25, 2025

  • 0 min

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  • 1

    The RESET trial evaluated the effectiveness of 60-day percutaneous peripheral nerve stimulation (PNS) for chronic low back pain (CLBP).

  • 2

    Two hundred thirty patients were randomized to receive either 60-day PNS or standard interventional care for CLBP management.

  • 3

    At 3 months, 55% of participants receiving PNS reported ≥50% pain relief compared to 26% in the usual care group (P < .001).

  • 4

    PNS treatment also led to significant improvements in disability, pain interference, quality of life, and analgesic consumption.

  • 5

    Pain relief and functional improvements from PNS were sustained through 6 months, indicating its potential as an effective treatment for CLBP.

Original Source(s)

Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain—a multicenter pragmatic randomized controlled trial (RESET)

  • by Zachary L McCormick, Denise D Lester, Michael J DePalma, Christopher A Gilmore, Sean Li, Jessica B Jameson, Mehul J Desai, Tristan E Weaver, Shivanand P Lad, Scott J Davidoff, Drew M Trainor, Kasra Amirdelfan, Mitchell P Engle, Timothy R Deer, Thomas S Lee, Francesco Vetri, Meenakshi Bindal, Melissa A Tornero-Bold, Morad N Nasseri, Steven P Cohen, William H Clark, Meredith J McGee, Joseph W Boggs

  • October 25, 2025

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