Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction - Takeaways - MDSpire

Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction

  • By

  • Jonas Dudda

  • Michael Behnes

  • Michelle Goertz

  • Felix Lau

  • Alexander Schmitt

  • Marielen Reinhardt

  • Noah Abel

  • Svetlana Hetjens

  • Daniel Duerschmied

  • Mohammad Abumayyaleh

  • Ibrahim Akin

  • Tobias Schupp

  • June 9, 2026

  • 0 min

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  • 1

    Heart failure with mildly reduced ejection fraction (HFmrEF) affects about one quarter of heart failure patients and is underrepresented in clinical studies.

  • 2

    C-reactive protein (CRP) is linked to systemic inflammation and has been associated with poor outcomes in heart failure patients.

  • 3

    The study investigates the prognostic impact of CRP levels on long-term mortality and rehospitalization in patients with HFmrEF.

  • 4

    Patients were categorized into four groups based on baseline CRP values during hospitalization to assess risk stratification.

  • 5

    The study utilized data from the Heart Failure with Mildly Reduced Ejection Fraction Registry (HARMER) at a University Medical Centre in Germany.

Original Source(s)

Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction

  • by Jonas Dudda, Michael Behnes, Michelle Goertz, Felix Lau, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Svetlana Hetjens, Daniel Duerschmied, Mohammad Abumayyaleh, Ibrahim Akin, Tobias Schupp

  • June 9, 2026

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