The Link Between Accelerated Biological Aging and the Inverse Relationship of Live Microbe Consumption with Diabetic Retinopathy in US Patients with Diabetes - Takeaways - MDSpire
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The Link Between Accelerated Biological Aging and the Inverse Relationship of Live Microbe Consumption with Diabetic Retinopathy in US Patients with Diabetes

  • By

  • Yining Zeng

  • Xiyue Tan

  • Hao Wu

  • Ruixia Wang

  • Yuxia Liu

  • Xueting Wang

  • Junguo Duan

  • February 28, 2026

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  • 1

    Diabetic retinopathy affects 20–30% of diabetic patients and is a leading cause of blindness, necessitating preventive strategies beyond current interventions.

  • 2

    The gut microbiota is linked to ocular diseases, with dietary live microbes potentially mitigating metabolic dysfunction and influencing diabetic retinopathy risk.

  • 3

    Accelerated biological aging, measured by PhenoAge and KDM-BA, may mediate the relationship between dietary live microbe intake and microvascular damage.

  • 4

    The study analyzed NHANES data from 2279 participants to explore the connections between dietary microbes, biological aging, and diabetic retinopathy.

  • 5

    Findings aim to provide insights into the eye-gut axis and dietary guidance for preventing diabetic retinopathy in patients with diabetes.

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