The role and therapeutic potential of nanotechnology-mediated ferroptosis regulation in myelodysplastic syndromes

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Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders with ineffective hematopoiesis and a risk of progression to acute myeloid leukemia.
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Excessive iron in MDS leads to oxidative stress and ferroptosis, which can worsen ineffective erythropoiesis in lower-risk patients.
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In higher-risk MDS, inducing ferroptosis in malignant cells may provide a potential therapeutic strategy.
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Current ferroptosis-targeting agents face challenges such as poor solubility, low stability, and potential toxicity to normal tissues.
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Nanotechnology may enhance ferroptosis regulation by improving drug delivery and targeting within the bone marrow microenvironment.

Frontiers In Oncology

by Wanhua An, Shuli Guo, Haojie Wang, Tao Lv, Wanli Wang, Bo Li, Mengyu Liu, Pu Yang, Farra Aidah Jumuddin
July 1, 2026

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