Independent prognostic value of the triglyceride–glucose index and its incremental predictive contribution beyond traditional risk markers in acute heart failure: a retrospective cohort study

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The study evaluated the prognostic significance of the triglyceride–glucose (TyG) index in patients with acute heart failure.
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Higher TyG levels were independently associated with an increased risk of cardiovascular death or rehospitalization.
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Patients in the highest TyG quartile had a significantly greater risk of adverse outcomes compared to those in the lowest quartile.
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TyG demonstrated a discriminative ability comparable to NT-proBNP for predicting adverse outcomes in acute heart failure.
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A combined model of TyG and NT-proBNP improved risk prediction beyond either marker alone in acute heart failure patients.

Frontiers In Cardiovascular Medicine

by Bolan Zhang, Bijian Wang, Lei Xia, Yaoyu Qi, Ying Xia, Binyan Lang, Yi Wang, Taidou Jiang, Yue Cao, Shuzhan Zheng
May 29, 2026

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