Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk - Takeaways - MDSpire

Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk

  • By

  • Jiawang Huang

  • Xiuli Xu

  • Yucheng Jin

  • Liping Qiao

  • Heng Yu

  • Wenbo Gao

  • Caie Li

  • June 4, 2026

  • 0 min

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  • 1

    Immune checkpoint inhibitors (ICIs) can induce immune-related myocarditis (ICI-MC), a rare but life-threatening toxicity with high mortality rates.

  • 2

    The pathogenesis of ICI-MC involves clonal expansion of cytotoxic CD8+ T cells and loss of regulatory T cells, leading to myocardial inflammation.

  • 3

    Crosstalk among various immune and stromal cells amplifies inflammation in ICI-MC through chemokine and complement activation.

  • 4

    A five-phase multicellular framework outlines the evolution of ICI-MC, highlighting critical stages from baseline autoreactivity to inflammatory amplification.

  • 5

    Identifying candidate biomarkers and targeted therapies is essential for precision strategies to mitigate ICI-induced cardiotoxicity.

Original Source(s)

Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk

  • by Jiawang Huang, Xiuli Xu, Yucheng Jin, Liping Qiao, Heng Yu, Wenbo Gao, Caie Li

  • June 4, 2026

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