Explainable residual ensemble modelling for EuroQol-5 dimensions-based quality-of-life assessment and stratification in patients with knee osteoarthritis

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Knee osteoarthritis (OA) significantly impacts quality of life (QoL) in older adults, with over one-third of those aged 65 and older affected in South Korea.
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Traditional statistical models struggle to capture the nonlinear interactions of factors influencing QoL in knee OA patients.
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The study proposes a residual ensemble framework combining logistic regression and Random Forest to enhance QoL assessment in knee OA.
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Data from 1,102 knee OA patients was analyzed, utilizing the EQ-5D index score to evaluate health-related QoL.
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The modeling framework aims to improve interpretability and predictive performance for personalized rehabilitation planning.

Digital Health

by Jaehyuk Lee, Sejun Oh, Jun Hwan Choi, Jin Taek Lee, Bo Ryun Kim, Sangheon Lee
June 18, 2026

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