Overcoming absolute dysphagia in a thirty-year-old patient with advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report - Takeaways - MDSpire

Overcoming absolute dysphagia in a thirty-year-old patient with advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report

  • By

  • Luca Carlofrancesco Ammoni

  • Giorgia Carola

  • Giuseppe Ippolito

  • Alice Baggi

  • Francesca Consoli

  • Andrea Esposito

  • Ilaria Pedrazzini

  • Alfredo Berruti

  • Salvatore Grisanti

  • May 28, 2026

  • 0 min

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  • 1

    ALK-positive non-small cell lung cancer (NSCLC) represents 3-7% of NSCLCs and primarily affects young, never-smoker patients.

  • 2

    Lorlatinib, a third-generation ALK TKI, is effective as first-line therapy but requires oral administration, posing challenges for patients with dysphagia.

  • 3

    A 30-year-old woman with advanced ALK-positive NSCLC experienced severe dysphagia due to lymphadenopathy compressing the cervical oesophagus.

  • 4

    Lorlatinib was administered via a nasogastric tube after crushing the tablets, leading to rapid improvement in swallowing and partial response in imaging.

  • 5

    After six months of treatment, the patient achieved a complete metabolic response, demonstrating the feasibility of enteral lorlatinib administration.

Original Source(s)

Overcoming absolute dysphagia in a thirty-year-old patient with advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report

  • by Luca Carlofrancesco Ammoni, Giorgia Carola, Giuseppe Ippolito, Alice Baggi, Francesca Consoli, Andrea Esposito, Ilaria Pedrazzini, Alfredo Berruti, Salvatore Grisanti

  • May 28, 2026

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