Risk-Stratified Transitional Care and Cardiovascular Hospitalizations by Sex: A Secondary Analysis of a

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Heart failure affects over 64 million patients globally, leading to significant morbidity, mortality, and healthcare costs.
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Females with heart failure experience a higher symptom burden and long-term readmission risk, despite lower hospitalization rates than males.
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The COACH trial tested a risk stratification strategy for acute heart failure in the emergency department, impacting discharge decisions and follow-up care.
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A prespecified subgroup analysis in the COACH trial aimed to determine if the intervention's benefits were consistent across sexes.
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The primary outcome of the trial was the composite of death or cardiovascular hospitalization within 30 days of emergency department presentation.

Jama Network Open

by Douglas S. Lee, Chang (Nancy) Wang, Peter C. Austin, Sharon E. Straus, Michael E. Farkouh, Alice Chong, Monica Taljaard, Stephanie Poon, Stuart Smith, Robert S. McKelvie, Robert M. Iwanochko, Andrea MacDougall, Esam Elbarasi, Peter M. Cram, Jiming Fang, Clare L. Atzema, Jacob A. Udell, Paula A. Rochon, Michael J. Schull, Susanna Mak, Heather J. Ross
May 12, 2026

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