Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B - Takeaways - MDSpire

Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B

  • By

  • Fangfang Li

  • Yi Li

  • Yirong Du

  • Chao Fan

  • Jun Xiong

  • Fei Hu

  • Xiaoying Deng

  • Xiaoyan Wang

  • Hongyan Shi

  • Xiangwei Sun

  • Xuyang Zheng

  • Ying Zhang

  • May 4, 2026

  • 0 min

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  • 1

    Chronic hepatitis B (CHB) remains a significant global health issue, with 254 million infections and 1.1 million deaths reported in 2022.

  • 2

    The immune-active phase of CHB is characterized by detectable HBV DNA and elevated ALT, marking a critical period for host-virus interactions.

  • 3

    Four hub genes, including SLC24A4, were identified as unique to the immune-active phase through bioinformatics and machine learning techniques.

  • 4

    SLC24A4 expression in peripheral classical monocytes was validated as significantly elevated during the immune-active phase compared to healthy controls.

  • 5

    The study suggests SLC24A4 may serve as a negative regulator of monocyte activation and a potential drug target for immune modulation in CHB.

Original Source(s)

Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B

  • by Fangfang Li, Yi Li, Yirong Du, Chao Fan, Jun Xiong, Fei Hu, Xiaoying Deng, Xiaoyan Wang, Hongyan Shi, Xiangwei Sun, Xuyang Zheng, Ying Zhang

  • May 4, 2026

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