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Three Genes May Help Distinguish RA From OA

Machine learning and cell-line validation identify candidate biomarkers for differentiating rheumatoid arthritis vs osteoarthritis

  • By

  • Andrea Surnit

  • April 22, 2026

  • 3 min

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  • 1

    Three candidate genes, EPYC, MAGED1, and LAP3, may help distinguish rheumatoid arthritis from osteoarthritis.

  • 2

    The study utilized machine learning methods on synovial-tissue data sets to identify potential diagnostic markers.

  • 3

    Receiver operating characteristic analyses showed good diagnostic performance with area under the curve values above 0.85.

  • 4

    Functional analyses indicated that differentially expressed genes in rheumatoid arthritis were enriched in immune-related pathways.

  • 5

    Further validation in independent clinical cohorts is necessary before these findings can be applied clinically.

Original Source(s)

Three Genes May Help Distinguish RA From OA

  • by Andrea Surnit

  • April 22, 2026

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