Risk factors associated with aggressive tumor phenotypes in papillary thyroid microcarcinoma: a systematic review and meta-analysis - Takeaways - MDSpire

Risk factors associated with aggressive tumor phenotypes in papillary thyroid microcarcinoma: a systematic review and meta-analysis

  • By

  • Máté Orgoványi

  • Anett Rancz

  • Anca Dolhascu

  • Gergely Agócs

  • Boglárka Lilla Szentes

  • Emese Sipter

  • Péter Hegyi

  • Gábor László Kovács

  • July 2, 2026

  • 0 min

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  • 1

    The study investigates clinical and molecular risk factors influencing aggressive phenotypes in papillary thyroid microcarcinoma (PTMC).

  • 2

    Key risk factors for central lymph node metastasis include male sex, age under 55, tumor size over 5 mm, multifocality, bilaterality, and BRAFV600E mutation.

  • 3

    Lateral lymph node metastasis is associated with similar risk factors, particularly male sex, younger age, larger tumor size, multifocality, and bilaterality.

  • 4

    Extrathyroidal extension risk factors include tumor size greater than 5 mm, multifocality, bilaterality, and the presence of BRAFV600E mutation.

  • 5

    The systematic review and meta-analysis adhered to PRISMA 2020 guidelines and was registered in PROSPERO under identifier CRD42024603662.

Original Source(s)

Risk factors associated with aggressive tumor phenotypes in papillary thyroid microcarcinoma: a systematic review and meta-analysis

  • by Máté Orgoványi, Anett Rancz, Anca Dolhascu, Gergely Agócs, Boglárka Lilla Szentes, Emese Sipter, Péter Hegyi, Gábor László Kovács

  • July 2, 2026

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