The regulatory roles of dysregulated lactate dehydrogenase A in anti-tumor immunity within immune cells - Takeaways - MDSpire

The regulatory roles of dysregulated lactate dehydrogenase A in anti-tumor immunity within immune cells

  • By

  • Xiaole Song

  • Shitong Lin

  • Qianwen Liu

  • Xuerou Chen

  • Yajuan Ma

  • Xiaoran Zhang

  • Fang Ren

  • June 17, 2026

  • 0 min

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  • 1

    Lactate dehydrogenase A (LDHA) is overexpressed in various malignancies and plays a crucial role in tumor metabolism and progression.

  • 2

    LDHA modulates the differentiation and function of tumor-infiltrating immune cells, influencing anti-tumor immune responses.

  • 3

    The review highlights the need to understand LDHA's role in immune cells, which is often overlooked in studies focused on tumor cells.

  • 4

    LDHA's metabolic effects on immune cells can lead to either pro-inflammatory or immunosuppressive phenotypes, depending on the tumor microenvironment.

  • 5

    Targeting LDHA may enhance the efficacy of immunotherapies, suggesting its potential as a therapeutic target in cancer treatment.

Original Source(s)

The regulatory roles of dysregulated lactate dehydrogenase A in anti-tumor immunity within immune cells

  • by Xiaole Song, Shitong Lin, Qianwen Liu, Xuerou Chen, Yajuan Ma, Xiaoran Zhang, Fang Ren

  • June 17, 2026

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