Effect of tegileridine pretreatment on fentanyl-induced cough during general anesthesia induction: a randomized controlled trial - Takeaways - MDSpire

Effect of tegileridine pretreatment on fentanyl-induced cough during general anesthesia induction: a randomized controlled trial

  • By

  • Shaojie Zhang

  • Jun Hu

  • Yajuan Zhao

  • Hongyi Xiao

  • Yonghao Hou

  • Huiwen Zheng

  • July 15, 2026

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  • 1

    Tegileridine pretreatment significantly reduced the incidence of fentanyl-induced cough (FIC) from 28.7% to 11.1% in a randomized controlled trial.

  • 2

    The study involved 216 adults undergoing elective surgery, who were randomized to receive either tegileridine or normal saline.

  • 3

    Cough severity was lower in the tegileridine group, with a relative risk reduction of 61.3% and an absolute risk reduction of 17.6%.

  • 4

    No significant differences in mean arterial pressure or heart rate changes were observed between the two groups.

  • 5

    Immediate adverse events were uncommon, suggesting tegileridine's safety during anesthetic induction.

Original Source(s)

Effect of tegileridine pretreatment on fentanyl-induced cough during general anesthesia induction: a randomized controlled trial

  • by Shaojie Zhang, Jun Hu, Yajuan Zhao, Hongyi Xiao, Yonghao Hou, Huiwen Zheng

  • July 15, 2026

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