Rethinking Prehabilitation Before Surgery - Takeaways - MDSpire

Rethinking Prehabilitation Before Surgery

Researchers compare personalized versus standard prehabilitation and examine functional, immune, and postoperative outcomes before major elective surgery.

  • By

  • Kathryn Wighton

  • February 2, 2026

  • 4 min

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  • 1

    Personalized prehabilitation, involving remote coaching, significantly improved preoperative immune signaling compared to standard approaches.

  • 2

    Patients receiving personalized prehabilitation showed broader improvements in physical and cognitive function before surgery.

  • 3

    Fewer moderate to severe postoperative complications were observed in the personalized prehabilitation group compared to the standard group.

  • 4

    The study utilized single-cell immune profiling to assess immune modulation, revealing specific changes in inflammatory signaling pathways.

  • 5

    Larger multicenter trials are needed to validate findings and develop scalable, biologically driven prehabilitation pathways.

Original Source(s)

Rethinking Prehabilitation Before Surgery

  • by Kathryn Wighton

  • February 2, 2026

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