Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age - Takeaways - MDSpire

Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age

  • By

  • Leizhen Xia

  • Wenting Xia

  • Lifeng Tian

  • Jialyu Huang

  • Houyang Chen

  • Li Cai

  • Leixiang Xia

  • Yan Zhao

  • Wei Gao

  • June 17, 2026

  • 0 min

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  • 1

    Luteinizing hormone (LH) supplementation during assisted reproductive technology (ART) may improve cumulative live birth rates (CLBR) in older women.

  • 2

    In a study of 2,316 women, rFSH+rLH showed a higher CLBR compared to rFSH alone (61.31% vs. 51.48%, P = 0.036).

  • 3

    The rFSH+HMG group required higher gonadotropin doses and longer stimulation duration than both rFSH+rLH and rFSH groups (P < 0.001).

  • 4

    Fresh embryo transfer outcomes did not significantly differ among the groups, indicating similar immediate reproductive potential.

  • 5

    Results suggest potential benefits of rLH supplementation, but causality cannot be inferred, and findings should be interpreted cautiously.

Original Source(s)

Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age

  • by Leizhen Xia, Wenting Xia, Lifeng Tian, Jialyu Huang, Houyang Chen, Li Cai, Leixiang Xia, Yan Zhao, Wei Gao

  • June 17, 2026

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