Aspirin is associated with improved outcomes in sepsis patients with atrial fibrillation: an analysis of the MIMIC-IV and eICU-CRD databases - Takeaways - MDSpire

Aspirin is associated with improved outcomes in sepsis patients with atrial fibrillation: an analysis of the MIMIC-IV and eICU-CRD databases

  • By

  • Fangchao Chen

  • Yufeng Zhong

  • Dianyang Wang

  • Qiuyin Wei

  • Rui Su

  • Hongfei Ge

  • Wencai Wei

  • Wei Wang

  • May 26, 2026

  • 0 min

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  • 1

    Sepsis involves dysregulated inflammation, endothelial injury, and thrombotic risk, particularly in patients with atrial fibrillation (AF).

  • 2

    A retrospective cohort study evaluated early aspirin exposure's association with mortality in sepsis patients with AF using MIMIC-IV and eICU-CRD databases.

  • 3

    In MIMIC-IV, early aspirin exposure was linked to lower 30-day all-cause mortality, with a hazard ratio of 0.624 in the fully adjusted model.

  • 4

    The association between early aspirin exposure and lower in-hospital mortality was significant in eICU-CRD, with a hazard ratio of 0.732.

  • 5

    Sensitivity analyses indicated that the mortality benefit of aspirin was primarily observed in patients newly initiated on aspirin within 48 hours after ICU admission.

Original Source(s)

Aspirin is associated with improved outcomes in sepsis patients with atrial fibrillation: an analysis of the MIMIC-IV and eICU-CRD databases

  • by Fangchao Chen, Yufeng Zhong, Dianyang Wang, Qiuyin Wei, Rui Su, Hongfei Ge, Wencai Wei, Wei Wang

  • May 26, 2026

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