A prospective evaluation of hidden bacterial involvement and antibiotic efficacy in nonbacterial CP/CPPS: addressing an underexplored therapeutic approach

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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by genitourinary pain without detectable uropathogenic bacteria.
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The study investigates the role of hidden bacterial pathogens in CPPS and evaluates the efficacy of antibiotic treatment for symptom relief.
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Participants included men with CPPS symptoms for at least 6 months, excluding those with other prostatitis categories or recent antibiotic use.
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Bacterial detection was performed using urine cultures and PCR for specific pathogens, guiding antibiotic treatment for positive cases.
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Symptom improvement was assessed using NIH-CPSI, IPSS, and OABSS scores before and after treatment at 1, 2, and 3 months.

World Journal Of Urology

by Hiroyuki Kitano, Hiroki Ohge, Kayoko Tadera, Yuki Kohada, Tomoya Hatayama, Hiroyuki Shikuma, Ryo Tasaka, Kenshiro Takemoto, Shunsuke Miyamoto, Kohei Kobatake, Yohei Sekino, Hiroki Kitagawa, Seiya Kashiyama, Nobuyuki Hinata
September 15, 2025

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