Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye

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The study identified predictors of treatment failure in outpatient management of uncomplicated skin and soft tissue infections (uSSTIs) in Türkiye.
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Higher BMI, chronic kidney disease, immunodeficiency, and lesion size were significant risk factors for hospitalization due to uSSTIs.
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Outpatient treatment failure was primarily due to persistent symptoms, often linked to inadequate antibiotic dosing or coverage.
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Laboratory predictors of hospitalization included elevated white blood cell count, neutrophil-to-lymphocyte ratio, and C-reactive protein levels.
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The study emphasizes the need for optimized treatment duration and early identification of high-risk patients to improve outcomes and reduce costs.

Bmc Infectious Diseases

by Melike Nur Özçelik, Merve Sefa Sayar, Nurten Nur Aydın, Dilşah Başkol Elik, Özgür Günal, Pınar Yürük Atasoy, Ayşegül Tuna, Cihan Semet, Serpil Erol, Azize Yetişgen, Yakup Gezer, Muhammet Rıdvan Tayşi, Naciye Betül Baysal, Gülden Eser Karlıdağ, Muammer Çelik, Emsal Aydın, Yeşim Kürekçi, Yasemin Akkoyunlu, Özay Akyıldız, Ayşe Serra Özel, Oktay Yapıcı, Deniz Özer, Şafak Kaya, Tuba Damar Çakırca, Şafak Balın Özer, İsmail Necati Hakyemez
December 27, 2025

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