Immunometabolic interactions in individuals with down syndrome across childhood, adolescence and adulthood in relation to their siblings - Takeaways - MDSpire

Immunometabolic interactions in individuals with down syndrome across childhood, adolescence and adulthood in relation to their siblings

  • By

  • Anna Tylutka

  • Agnieszka Zembron-Lacny

  • Marta Hetman

  • Aleksandra Bodetko

  • Helena Moreira

  • Ewa Barg

  • July 7, 2026

  • 0 min

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  • 1

    Down syndrome (DS) is the most common chromosomal disorder, leading to immune dysregulation and increased cardiovascular disease risk.

  • 2

    The study involved 63 individuals, with 42 having DS and 21 as controls, analyzing their immunological and metabolic profiles.

  • 3

    Children with DS showed significantly higher obesity rates and elevated levels of non-HDL and apoB compared to controls.

  • 4

    Lower levels of cytokines IL-10, IL-13, and IL-22 were found in the DS group, indicating altered immune responses.

  • 5

    The presence of an additional chromosome 21 in DS leads to significant changes in immune system function and metabolic disorders.

Original Source(s)

Immunometabolic interactions in individuals with down syndrome across childhood, adolescence and adulthood in relation to their siblings

  • by Anna Tylutka, Agnieszka Zembron-Lacny, Marta Hetman, Aleksandra Bodetko, Helena Moreira, Ewa Barg

  • July 7, 2026

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