Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management - Takeaways - MDSpire

Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management

  • By

  • Chang Shi

  • Ying Zhao

  • Wei Liu

  • Runqi Gong

  • Yinan Duan

  • Wenli Yu

  • June 18, 2026

  • 0 min

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  • 1

    Endometrial dysfunction is a major factor in recurrent implantation failure and infertility, affecting approximately 10% of infertility cases.

  • 2

    Key pathogenic drivers of endometrial impairment include cellular senescence, chronic inflammation, and endometriosis, impacting embryo implantation.

  • 3

    Therapeutic interventions like intrauterine platelet-rich plasma infusion show promise but require validation through large, randomized trials.

  • 4

    Granulocyte colony-stimulating factor, peripheral blood mononuclear cells, and stem cell therapies also exhibit potential but need further research.

  • 5

    This review integrates mechanistic insights with clinical applications, providing a foundation for personalized treatment strategies in reproductive medicine.

Original Source(s)

Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management

  • by Chang Shi, Ying Zhao, Wei Liu, Runqi Gong, Yinan Duan, Wenli Yu

  • June 18, 2026

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