The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease - Takeaways - MDSpire

The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease

  • By

  • Alexandra Noble

  • Alex Adams

  • Jan Nowak

  • Guo Cheng

  • Komal Nayak

  • Aisling Quinn

  • Mark Kristiansen

  • Rahul Kalla

  • Nicholas T Ventham

  • Federica Giachero

  • Chamara Jayamanne

  • Richard Hansen

  • Georgina L Hold

  • Emad El-Omar

  • Nicholas M Croft

  • David Wilson

  • R Mark Beattie

  • James J Ashton

  • Matthias Zilbauer

  • Sarah Ennis

  • Holm H Uhlig

  • Jack Satsangi

  • October 4, 2024

  • 0 min

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  • 1

    The study analyzes the circulating methylome in 86 pediatric IBD patients and 30 controls using the Illumina Infinium Human MethylationEPIC platform.

  • 2

    A 4-probe methylation biomarker was validated, demonstrating high diagnostic accuracy for pediatric IBD with an area under the curve of 0.90-0.94.

  • 3

    Significant epigenetic age acceleration was observed at diagnosis, particularly pronounced in patients with Crohn's disease.

  • 4

    Cis-methylation quantitative trait loci analysis identified genetic determinants of epigenetic alterations, especially in the HLA region.

  • 5

    Passive smoking exposure was linked to ulcerative colitis development, contrasting with previous findings that suggested no such association.

Original Source(s)

The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease

  • by Alexandra Noble, Alex Adams, Jan Nowak, Guo Cheng, Komal Nayak, Aisling Quinn, Mark Kristiansen, Rahul Kalla, Nicholas T Ventham, Federica Giachero, Chamara Jayamanne, Richard Hansen, Georgina L Hold, Emad El-Omar, Nicholas M Croft, David Wilson, R Mark Beattie, James J Ashton, Matthias Zilbauer, Sarah Ennis, Holm H Uhlig, Jack Satsangi

  • October 4, 2024

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