Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury - Takeaways - MDSpire

Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury

  • By

  • Elizabeth W. Tindal

  • Chun-Shiang Chung

  • Yaping Chen

  • Runping Zhao

  • Fernando Gutierrez Garcia

  • Theopi Rados

  • Sean F. Monaghan

  • Alfred Ayala

  • June 2, 2026

  • 0 min

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  • 1

    Endothelial cell-specific loss of PD-L1 significantly reduces lung injury and mortality in murine models of shock and sepsis.

  • 2

    Neutrophil-specific loss of PD-L1 increases mortality and lung injury, highlighting a contrasting role of PD-L1 in different cell types.

  • 3

    Lung vascular permeability decreased in ecPD-L1−/− mice, indicating protective effects against lung injury.

  • 4

    Cytokine and chemokine levels were altered in ecPD-L1−/− mice, suggesting a complex immune response in lung injury.

  • 5

    The study reveals a potential immune protective role of PD-L1 on neutrophils, contrasting its detrimental impact on endothelial cells.

Original Source(s)

Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury

  • by Elizabeth W. Tindal, Chun-Shiang Chung, Yaping Chen, Runping Zhao, Fernando Gutierrez Garcia, Theopi Rados, Sean F. Monaghan, Alfred Ayala

  • June 2, 2026

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