Development and external validation of a parsimonious lactate-to-diastolic blood pressure ratio model for 28-day mortality risk stratification in septic shock: a retrospective two-cohort study - Takeaways - MDSpire

Development and external validation of a parsimonious lactate-to-diastolic blood pressure ratio model for 28-day mortality risk stratification in septic shock: a retrospective two-cohort study

  • By

  • Ziang Li

  • Wanglin Zhang

  • Kanlirong Wang

  • Tong Jin

  • Liqun Sun

  • June 15, 2026

  • 0 min

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  • 1

    A simplified model using the lactate-to-diastolic blood pressure ratio (LDR) predicts 28-day mortality in septic shock patients with invasive monitoring.

  • 2

    The study included 320 patients from an institutional ICU and 962 from MIMIC-IV, assessing LDR's performance in predicting mortality.

  • 3

    LDR × 100 demonstrated consistent discrimination with AUCs of 0.726 and 0.714 in development and validation cohorts, respectively.

  • 4

    Calibration drift was observed in external validation, indicating the need for local recalibration of LDR-based risk estimates.

  • 5

    LDR provides complementary risk assessment in the lactate gray zone but requires prospective validation before clinical use.

Original Source(s)

Development and external validation of a parsimonious lactate-to-diastolic blood pressure ratio model for 28-day mortality risk stratification in septic shock: a retrospective two-cohort study

  • by Ziang Li, Wanglin Zhang, Kanlirong Wang, Tong Jin, Liqun Sun

  • June 15, 2026

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