Efficacy and safety of linaclotide plus polyethylene glycol for bowel preparation before colonoscopy in elderly Chinese patients: a systematic review and meta-analysis

1

The study included 12 randomized controlled trials with 1,334 participants, comparing Linaclotide plus PEG to PEG alone in elderly Chinese adults.
2

Linaclotide combined with PEG significantly improved bowel cleansing quality and reduced total procedure time compared to PEG alone.
3

Participants receiving Lin + PEG experienced lower risks of vomiting, abdominal pain, abdominal distension, and nausea.
4

No significant difference in total adverse events was observed between the Lin + PEG group and the PEG alone group.
5

The polyp detection rate was higher in the Lin + PEG group, indicating potential benefits in identifying lesions during colonoscopy.

Frontiers In Medicine

by Shuaijun Li, Haixing Wei, Jiawei Wang, Xinyue Su, Qing Wu, Jie Wang, Peng Peng, Mengbin Qin
July 7, 2026

1