Differential immunologic response to GnRHa alone vs. dual trigger for final follicular maturation: a proof-of-concept pilot study - Takeaways - MDSpire

Differential immunologic response to GnRHa alone vs. dual trigger for final follicular maturation: a proof-of-concept pilot study

  • By

  • Raoul Orvieto

  • Helly Vernitsky

  • Marina Safanaiev

  • Dolly Yuster

  • Dan Dominissini

  • July 10, 2026

  • 0 min

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  • 1

    The study compared immune responses in women undergoing oocyte cryopreservation using GnRHa versus dual trigger (GnRHa plus hCG).

  • 2

    Five healthy women participated, with three receiving GnRHa trigger and two receiving dual trigger, in a prospective pilot study.

  • 3

    Dual trigger was associated with a trend toward a lower CD4/CD8 T cell ratio and an increase in CD57+ cytotoxic cell populations compared to GnRHa alone.

  • 4

    Findings are exploratory and should not be interpreted as definitive due to the small sample size and lack of randomization.

  • 5

    The study highlights the need for larger, randomized cohorts to validate the observed immune profile shifts and their implications.

Original Source(s)

Differential immunologic response to GnRHa alone vs. dual trigger for final follicular maturation: a proof-of-concept pilot study

  • by Raoul Orvieto, Helly Vernitsky, Marina Safanaiev, Dolly Yuster, Dan Dominissini

  • July 10, 2026

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