Development of a BM7G(TKO/hCD46/hCD55/hTHBD/hEPCR) donor pig with endogenous promoter-driven transgenes for xenotransplantation - Takeaways - MDSpire

Development of a BM7G(TKO/hCD46/hCD55/hTHBD/hEPCR) donor pig with endogenous promoter-driven transgenes for xenotransplantation

  • By

  • Cong Xia

  • Meng Lian

  • Bingxiu Ma

  • Hongliang Yu

  • Renquan Zhang

  • Lijia Wen

  • Xueliang Wang

  • Yu Zhao

  • Zhen Ouyang

  • Yinghua Ye

  • Xiner Feng

  • Han Wu

  • Liangxue Lai

  • June 23, 2026

  • 0 min

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  • 1

    Xenotransplantation aims to address organ shortages through genetically modified pigs with enhanced xenograft survival.

  • 2

    CRISPR-Cas9 technology was utilized to knockout three glycan antigen genes, reducing hyperacute rejection in pigs.

  • 3

    Four human protective genes were integrated into the porcine Rosa26 locus, ensuring stable expression driven by endogenous promoters.

  • 4

    BM7G genetically modified pigs showed complete absence of glycan antigens and stable expression of protective proteins in major organs.

  • 5

    The study successfully created a seven-gene modified pig model with low immunogenicity, providing a resource for xenotransplantation research.

Original Source(s)

Development of a BM7G(TKO/hCD46/hCD55/hTHBD/hEPCR) donor pig with endogenous promoter-driven transgenes for xenotransplantation

  • by Cong Xia, Meng Lian, Bingxiu Ma, Hongliang Yu, Renquan Zhang, Lijia Wen, Xueliang Wang, Yu Zhao, Zhen Ouyang, Yinghua Ye, Xiner Feng, Han Wu, Liangxue Lai

  • June 23, 2026

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