Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver–bone model - Takeaways - MDSpire

Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver–bone model

  • By

  • Mohammad Majd Hammour

  • Lisa Herzberger

  • Yuxuan Xin

  • Guanqiao Chen

  • Melike Tombaz

  • Sabrina Ehnert

  • Fabian Springer

  • Georg Damm

  • Massoud Vosough

  • Jan G. Hengstler

  • Ursula Müller-Vieira

  • Andreas K. Nüssler

  • Romina H. Aspera-Werz

  • May 13, 2026

  • 0 min

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  • 1

    Metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly 30% of the global population and is linked to systemic metabolic disorders.

  • 2

    Vitamin D insufficiency in MASLD patients correlates with reduced bone mineral density and increased fracture risk, highlighting its impact on bone health.

  • 3

    Disrupted hepatic vitamin D metabolism in MASLD may impair bone mineralization and mechanical stiffness due to reduced expression of key enzymes.

  • 4

    A novel 3D human liver-bone in vitro model was developed to study the effects of MASLD on bone formation and degradation.

  • 5

    The study hypothesized that MASLD suppresses CYP2R1/CYP27A1 expression, leading to impaired vitamin D metabolism and subsequent bone health issues.

Original Source(s)

Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver–bone model

  • by Mohammad Majd Hammour, Lisa Herzberger, Yuxuan Xin, Guanqiao Chen, Melike Tombaz, Sabrina Ehnert, Fabian Springer, Georg Damm, Massoud Vosough, Jan G. Hengstler, Ursula Müller-Vieira, Andreas K. Nüssler, Romina H. Aspera-Werz

  • May 13, 2026

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