Imaging for molecular and pathological subtyping of hepatocellular carcinoma—a critical appraisal and future directions - Takeaways - MDSpire

Imaging for molecular and pathological subtyping of hepatocellular carcinoma—a critical appraisal and future directions

  • By

  • Xinyuan Jia

  • Hanyu Jiang

  • Zheng Ye

  • Hong Wei

  • Jie Chen

  • Yali Qu

  • Claude B. Sirlin

  • Bin Song

  • Yanshu Wang

  • October 30, 2025

  • 0 min

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  • 1

    Hepatocellular carcinoma (HCC) exhibits biological heterogeneity, complicating management and influencing recurrence and therapeutic response.

  • 2

    Molecular classifications of HCC include proliferative and non-proliferative classes, each associated with distinct clinical outcomes and characteristics.

  • 3

    Proliferative HCC is linked to chronic HBV infection and aggressive phenotypes, while non-proliferative HCC is associated with better clinical outcomes.

  • 4

    Pathological subtypes of HCC include conventional HCC and eight distinct subtypes, with a complex relationship between molecular and pathological classifications.

  • 5

    Imaging features may help infer molecular and pathological characteristics of HCC, potentially improving noninvasive prognostication and treatment predictions.

Original Source(s)

Imaging for molecular and pathological subtyping of hepatocellular carcinoma—a critical appraisal and future directions

  • by Xinyuan Jia, Hanyu Jiang, Zheng Ye, Hong Wei, Jie Chen, Yali Qu, Claude B. Sirlin, Bin Song, Yanshu Wang

  • October 30, 2025

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