Surfactant protein D: prognostic insights and emerging therapeutic roles in cancer - Takeaways - MDSpire

Surfactant protein D: prognostic insights and emerging therapeutic roles in cancer

  • By

  • Sharon Ajay Mathew

  • Sushama Rokade

  • K.G. Aghila Rani

  • Hrishikesh Pandit

  • Uday Kishore

  • Taruna Madan

  • July 9, 2026

  • 0 min

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  • 1

    Surfactant protein D (SP-D) is crucial for innate immunity and is expressed in various tissues beyond the lungs.

  • 2

    SP-D shows differential expression in lung adenocarcinoma and metastases, indicating its potential as a prognostic marker.

  • 3

    Recombinant SP-D has demonstrated direct anti-tumor effects in various cancers, including leukemia and breast cancer.

  • 4

    SP-D interacts with the epidermal growth factor receptor, inhibiting cancer cell proliferation and metastasis.

  • 5

    Altered SP-D expression is associated with multiple malignancies, including lung, breast, and prostate cancers.

Original Source(s)

Surfactant protein D: prognostic insights and emerging therapeutic roles in cancer

  • by Sharon Ajay Mathew, Sushama Rokade, K.G. Aghila Rani, Hrishikesh Pandit, Uday Kishore, Taruna Madan

  • July 9, 2026

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