High-Risk Smoldering Multiple Myeloma: BCMA-Directed CAR T-Cell Therapy Shows Activity - Takeaway - MDSpire
From the Journals

High-Risk Smoldering Multiple Myeloma: BCMA-Directed CAR T-Cell Therapy Shows Activity

A single infusion of the chimeric antigen receptor (CAR) T-cell therapy ciltacabtagene autoleucel led to a 100% measurable residual disease (MRD)-negativity rate in patients with high-risk smoldering ...

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    Ciltacabtagene autoleucel shows 100% MRD negativity in high-risk SMM patients.

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    The CAR-PRISM trial involved 20 patients at Dana-Farber Cancer Institute.

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    No instances of disease progression were observed during follow-up.

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    This therapy intercepts the disease before it develops symptoms.

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    The FDA approved this therapy for use in relapsed multiple myeloma.

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    Patients showed low-grade cytokine-release syndromes post-treatment.

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    Early intervention with CAR T-cell therapy may lead to deeper responses.

Original Source(s)

High-Risk Smoldering Multiple Myeloma: BCMA-Directed CAR T-Cell Therapy Shows Activity

  • by The ASCO Post Staff

  • April 21, 2026

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