Systematic Review of Urinary Biomarkers for the Detection of Renal Cell Carcinoma - Takeaways - MDSpire

Systematic Review of Urinary Biomarkers for the Detection of Renal Cell Carcinoma

  • By

  • Jaycey F. Kelly

  • Iryna V. Samarska

  • Bram Ramaekers

  • Tom Marcelissen

  • Joep G. van Roermund

  • Maureen J. B. Aarts

  • Thomas Kerkhofs

  • Tom Hermans

  • Frits van Osch

  • Tim de Meyer

  • Leo J. Schouten

  • Kim M. Smits

  • October 30, 2025

  • 0 min

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  • 1

    Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for 90% of cases, with a mean diagnosis age of 75 years.

  • 2

    The mortality rate for kidney cancer has decreased from 180,000 in 2020 to 156,000 in 2022, according to GLOBOCAN estimates.

  • 3

    Improved imaging techniques have led to increased detection of small renal lesions, but 20-30% of these are benign, leading to unnecessary surgeries.

  • 4

    This systematic review identifies urinary biomarkers for RCC, aiming to enhance early detection and reduce unnecessary nephrectomies.

  • 5

    Only 46 studies met the inclusion criteria, with selection bias being the most common issue identified in the quality assessment.

Original Source(s)

Systematic Review of Urinary Biomarkers for the Detection of Renal Cell Carcinoma

  • by Jaycey F. Kelly, Iryna V. Samarska, Bram Ramaekers, Tom Marcelissen, Joep G. van Roermund, Maureen J. B. Aarts, Thomas Kerkhofs, Tom Hermans, Frits van Osch, Tim de Meyer, Leo J. Schouten, Kim M. Smits

  • October 30, 2025

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