Case Report: Pediatric MOG/NMDAR overlap syndrome with delayed cortical MRI evolution and incidental venous sinus hypoplasia - Takeaways - MDSpire

Case Report: Pediatric MOG/NMDAR overlap syndrome with delayed cortical MRI evolution and incidental venous sinus hypoplasia

  • By

  • Wenqing Cao

  • Zezhen Chen

  • Mei Liu

  • Jin Wu

  • July 3, 2026

  • 0 min

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  • 1

    A 16-year-old girl presented with progressive headache and focal deficits, leading to a diagnosis of MNOS-associated MOGAD cortical encephalitis.

  • 2

    Initial imaging suggested CVST due to unilateral sinus non-visualization, but subsequent reassessment indicated a low-flow variant instead.

  • 3

    CSF analysis revealed inflammatory abnormalities, with positive anti-NMDAR-IgG and MOG-IgG, supporting the diagnosis of overlapping conditions.

  • 4

    The patient improved after treatment with high-dose corticosteroids and intravenous immunoglobulin, with no further seizures reported.

  • 5

    This case emphasizes the importance of longitudinal reassessment in distinguishing MNOS-related MOGAD from infectious and vascular mimics.

Original Source(s)

Case Report: Pediatric MOG/NMDAR overlap syndrome with delayed cortical MRI evolution and incidental venous sinus hypoplasia

  • by Wenqing Cao, Zezhen Chen, Mei Liu, Jin Wu

  • July 3, 2026

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