Microbiota-mediated mechanisms of natural products in atherosclerosis: focus on metabolic and inflammatory pathways - Takeaways - MDSpire

Microbiota-mediated mechanisms of natural products in atherosclerosis: focus on metabolic and inflammatory pathways

  • By

  • Qi Shen

  • Ce Bian

  • Mengjun Zhou

  • Xingkun Shen

  • Xiaodong Jin

  • Bo Li

  • June 26, 2026

  • 0 min

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  • 1

    Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation and plaque formation, influenced by gut microbiota dysbiosis.

  • 2

    Natural products like polyphenols and flavonoids can modulate atherosclerosis by reshaping gut microbial ecology and metabolic outputs.

  • 3

    These natural products reduce harmful metabolites like trimethylamine N-oxide and promote beneficial short-chain fatty acids.

  • 4

    Current evidence primarily comes from animal and in vitro studies, with clinical studies facing limitations such as small sample sizes.

  • 5

    Future research should focus on standardized preparations and well-designed clinical trials to validate the therapeutic potential of natural products.

Original Source(s)

Microbiota-mediated mechanisms of natural products in atherosclerosis: focus on metabolic and inflammatory pathways

  • by Qi Shen, Ce Bian, Mengjun Zhou, Xingkun Shen, Xiaodong Jin, Bo Li

  • June 26, 2026

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