Identification of Distinct Biopsychosocial Phenotypes in Young Adults with Chronic Postsurgical Pain through Resting-State Cortical Activity, Biomarkers, and Functional Performance - Takeaways - MDSpire

Identification of Distinct Biopsychosocial Phenotypes in Young Adults with Chronic Postsurgical Pain through Resting-State Cortical Activity, Biomarkers, and Functional Performance

  • By

  • Guillermo Ceniza-Bordallo

  • Ziyan Wu

  • Caitlin Curry

  • Christine B. Sieberg

  • April 29, 2026

  • 0 min

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  • 1

    Chronic postsurgical pain (CPSP) affects 10%-20% of young adults post-surgery, leading to significant functional impairments and emotional distress.

  • 2

    The study identified two distinct CPSP phenotypes in young adults: low functioning and high functioning, differing in pain catastrophizing and autonomic reactivity.

  • 3

    AYAs with CPSP exhibited greater pain interference and dysregulated physiological responses to exertion compared to healthy controls.

  • 4

    Psychological distress, hair cortisol levels, physical performance, and resting-state cortical activity were interrelated within the CPSP group.

  • 5

    Integrating physiological biomarkers and neuroimaging with performance assessments may enhance understanding and treatment of CPSP in young adults.

Original Source(s)

Identification of Distinct Biopsychosocial Phenotypes in Young Adults with Chronic Postsurgical Pain through Resting-State Cortical Activity, Biomarkers, and Functional Performance

  • by Guillermo Ceniza-Bordallo, Ziyan Wu, Caitlin Curry, Christine B. Sieberg

  • April 29, 2026

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