Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis - Takeaways - MDSpire

Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis

  • By

  • Seng Fan

  • Ziyue Gai

  • Hui Ma

  • Ziye Wen

  • Chunlei Ma

  • Dongying Fan

  • Songying Qian

  • Zengxin Li

  • April 13, 2026

  • 0 min

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  • 1

    Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, significantly impacting vision and quality of life.

  • 2

    This meta-analysis included 34 studies with 383,195 patients, revealing a bidirectional relationship between DR and both anxiety and depression.

  • 3

    A significant positive correlation was found between DR and depression (OR = 1.58) and between depression and DR (OR = 2.13), indicating mutual influence.

  • 4

    The analysis also showed a positive correlation between DR and anxiety (OR = 2.23), suggesting that psychological factors affect DR outcomes.

  • 5

    Personalized psychological care is recommended for patients with DR to improve treatment compliance and overall quality of life.

Original Source(s)

Bidirectional relationship of diabetic retinopathy with anxiety and depression: a meta-analysis

  • by Seng Fan, Ziyue Gai, Hui Ma, Ziye Wen, Chunlei Ma, Dongying Fan, Songying Qian, Zengxin Li

  • April 13, 2026

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