A case report: Retroperitoneal dedifferentiated liposarcoma with heterologous myogenic differentiation and testicular metastasis - Takeaways - MDSpire

A case report: Retroperitoneal dedifferentiated liposarcoma with heterologous myogenic differentiation and testicular metastasis

  • By

  • 马, 浩淞

  • Zi, Guo Run

  • Li, Yiqing

  • Xu, Quanlv

  • Ke, Changxing

  • June 22, 2026

  • 0 min

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  • 1

    Dedifferentiated liposarcoma (DDLPS) is the most common retroperitoneal soft tissue sarcoma, characterized by MDM2 and CDK4 gene co-amplification.

  • 2

    DDLPS with heterologous myogenic differentiation is rare and can be misclassified as primary rhabdomyosarcoma due to myogenic marker expression.

  • 3

    Testicular metastasis of DDLPS is rare, with only isolated case reports documented in the literature.

  • 4

    A 46-year-old male presented with a retroperitoneal mass, later developing a right scrotal mass postoperatively.

  • 5

    FISH analysis confirmed MDM2 and CDK4 amplification, establishing the diagnosis of DDLPS with myogenic differentiation.

Original Source(s)

A case report: Retroperitoneal dedifferentiated liposarcoma with heterologous myogenic differentiation and testicular metastasis

  • by 马, 浩淞 , Zi, Guo Run , Li, Yiqing , Xu, Quanlv , Ke, Changxing

  • June 22, 2026

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