Hereditary Variant Drives Deadly Prostate Cancer - Takeaways - MDSpire

Hereditary Variant Drives Deadly Prostate Cancer

Researchers find rare germline CDK12 variants in patients with aggressive prostate cancer, with implications for molecular diagnostics

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Inherited variants in the CDK12 gene may predispose patients to aggressive metastatic prostate cancer.
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The study published in Cancer Discovery challenges the view that CDK12 alterations are only acquired mutations.
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Researchers analyzed data from 4,535 patients and found five with inherited truncating CDK12 variants.
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All five patients diagnosed with high-grade metastatic prostate cancer had a second somatic CDK12 alteration.
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The findings suggest a need to consider CDK12 for hereditary prostate cancer testing and further investigation.