Polymyxin B-induced acute kidney injury in a burn patient: a case report and pharmaceutical care - Takeaways - MDSpire

Polymyxin B-induced acute kidney injury in a burn patient: a case report and pharmaceutical care

  • By

  • Shanshan Ding

  • May 7, 2026

  • 0 min

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  • 1

    Polymyxin B is increasingly used for multidrug-resistant Gram-negative infections but poses a significant risk of acute kidney injury (AKI).

  • 2

    A 44-year-old male burn patient developed AKI after increasing doses of polymyxin B, with serum creatinine rising from 59 to 163 μmol/L in 3 days.

  • 3

    The Naranjo score indicated a probable link between polymyxin B and AKI, necessitating a dosage reduction to improve renal function.

  • 4

    Monitoring renal function within 3 days of polymyxin B administration is crucial, especially in burn patients at high risk for AKI.

  • 5

    Therapeutic drug surveillance and dosage adjustments based on renal biomarkers are essential for safe polymyxin B use in vulnerable patients.

Original Source(s)

Polymyxin B-induced acute kidney injury in a burn patient: a case report and pharmaceutical care

  • by Shanshan Ding

  • May 7, 2026

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