Bile acids and bile acid modification in health and disease: from novel modifications to therapeutic interventions - Takeaways - MDSpire

Bile acids and bile acid modification in health and disease: from novel modifications to therapeutic interventions

  • By

  • Chuying Yu

  • Xintong Ye

  • Haoyu Zhao

  • Suting Qian

  • Feifei Xie

  • Qingsheng Liu

  • June 4, 2026

  • 0 min

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  • 1

    Bile acids (BAs) function as lipid-digesting molecules and signaling mediators in metabolism and immune regulation.

  • 2

    Microbiota-driven modifications of BAs enhance their diversity and link gut dysbiosis to metabolic disorders and inflammation.

  • 3

    Novel BA modifications, such as 3-succinylated cholic acid, show potential in treating metabolic dysfunction-associated steatohepatitis.

  • 4

    Therapeutic strategies targeting BA signaling pathways, including FXR and TGR5, are being explored for various diseases.

  • 5

    Advancements in multi-omics and AI approaches are accelerating the translation of BA-based interventions into clinical practice.

Original Source(s)

Bile acids and bile acid modification in health and disease: from novel modifications to therapeutic interventions

  • by Chuying Yu, Xintong Ye, Haoyu Zhao, Suting Qian, Feifei Xie, Qingsheng Liu

  • June 4, 2026

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