The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives - Takeaways - MDSpire

The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives

  • By

  • Zhongjun Wang

  • QingYuan Bian

  • Yue Chu

  • Wanyue Zhu

  • Ying Qin

  • Jiwei Zheng

  • May 26, 2026

  • 0 min

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  • 1

    Oral squamous cell carcinoma is the most common head and neck malignancy, yet survival rates have not significantly improved.

  • 2

    Chronic inflammation from periodontitis contributes to oral squamous cell carcinoma progression through immune dysregulation.

  • 3

    Dysbiosis of the oral microbiota is linked to oral squamous cell carcinoma, with specific microorganisms promoting carcinogenesis.

  • 4

    The proposed 'microbiome-inflammation-immune axis' illustrates the interactions between microbiota, inflammation, and tumor immunity.

  • 5

    Clinical indicators, including inflammatory and salivary markers, are essential for diagnosing and treating oral squamous cell carcinoma.

Original Source(s)

The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives

  • by Zhongjun Wang, QingYuan Bian, Yue Chu, Wanyue Zhu, Ying Qin, Jiwei Zheng

  • May 26, 2026

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