Is atypical parathyroid tumor a different clinical entity than parathyroid adenoma and carcinoma? A retrospective review of a large single-center case series - Takeaways - MDSpire

Is atypical parathyroid tumor a different clinical entity than parathyroid adenoma and carcinoma? A retrospective review of a large single-center case series

  • By

  • C. Maconi

  • A. M. Saibene

  • L. Castellani

  • P. Lozza

  • C. Pescia

  • M. Falleni

  • L. De Pasquale

  • October 29, 2025

  • 0 min

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  • 1

    Primary hyperparathyroidism (PHPT) is primarily caused by single-gland pathology in 80-85% of cases, with parathyroid adenoma being the most common.

  • 2

    Atypical parathyroid tumor (APT) is defined as a neoplasm with uncertain malignant potential, lacking definitive evidence of invasive growth.

  • 3

    The incidence of atypical parathyroid tumor ranges from 0.5 to 4.4%, with a higher prevalence in females.

  • 4

    A retrospective study analyzed 352 patients who underwent parathyroidectomy for single-gland PHPT to evaluate differences between APT and other parathyroid lesions.

  • 5

    Post-operative complications included transient and permanent hypoparathyroidism, with specific definitions for hypocalcemia and hypoparathyroidism established.

Original Source(s)

Is atypical parathyroid tumor a different clinical entity than parathyroid adenoma and carcinoma? A retrospective review of a large single-center case series

  • by C. Maconi, A. M. Saibene, L. Castellani, P. Lozza, C. Pescia, M. Falleni, L. De Pasquale

  • October 29, 2025

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