CD19-negative non-IgM type lymphoplasmacytic lymphoma: a case report and literature review - Takeaways - MDSpire

CD19-negative non-IgM type lymphoplasmacytic lymphoma: a case report and literature review

  • By

  • Feng Lu

  • Fugang Li

  • Hongying Zhan

  • Yuanfeng Huang

  • Rong Huang

  • Xuchuan Jiang

  • Chengjie Ji

  • Gang Wang

  • Tao Chen

  • Xia Fu

  • Tao Wei

  • Weijie Jiang

  • July 13, 2026

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  • 1

    Non-IgM type lymphoplasmacytic lymphoma (LPL) is a rare entity that poses significant diagnostic challenges.

  • 2

    A 69-year-old man was diagnosed with CD19-negative non-IgM type LPL after elevated M-protein and globulin levels were found.

  • 3

    Bone marrow biopsy showed normocellular marrow with approximately 40% cellularity and no characteristic lymphoid aggregates.

  • 4

    Flow cytometry identified a CD19-negative, CD20-positive monoclonal B lymphocyte population coexisting with plasma cells.

  • 5

    The diagnosis of CD19-negative non-IgM type LPL was established through a comprehensive integration of various diagnostic methods.

Original Source(s)

CD19-negative non-IgM type lymphoplasmacytic lymphoma: a case report and literature review

  • by Feng Lu, Fugang Li, Hongying Zhan, Yuanfeng Huang, Rong Huang, Xuchuan Jiang, Chengjie Ji, Gang Wang, Tao Chen, Xia Fu, Tao Wei, Weijie Jiang

  • July 13, 2026

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