Perampanel use in pediatric autoimmune encephalitis-related seizures and epilepsy: a retrospective case series - Takeaways - MDSpire

Perampanel use in pediatric autoimmune encephalitis-related seizures and epilepsy: a retrospective case series

  • By

  • Jiaqin Yi

  • Qing Lu

  • Ling Hu

  • Jiehui Ma

  • Qiaoqiao Qian

  • Dan Sun

  • May 26, 2026

  • 0 min

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  • 1

    This study evaluated the efficacy of perampanel (PER) in treating seizures in pediatric patients with autoimmune encephalitis (AE).

  • 2

    Fourteen pediatric patients with AE were treated with PER, showing seizure improvement without serious adverse events.

  • 3

    In the acute symptomatic seizures group, 42.8% achieved seizure resolution during the acute phase after PER administration.

  • 4

    In the autoimmune-associated epilepsy group, 57.1% had a ≥ 50% reduction in seizure frequency at the 3-month endpoint.

  • 5

    The findings suggest PER may be beneficial for AE-related seizures, but results should be interpreted as preliminary due to concomitant treatments.

Original Source(s)

Perampanel use in pediatric autoimmune encephalitis-related seizures and epilepsy: a retrospective case series

  • by Jiaqin Yi, Qing Lu, Ling Hu, Jiehui Ma, Qiaoqiao Qian, Dan Sun

  • May 26, 2026

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