Dietary fibers to boost endogenous GLP-1 secretion and satiety: a scoping review - Takeaways - MDSpire

Dietary fibers to boost endogenous GLP-1 secretion and satiety: a scoping review

  • By

  • Jelle C. B. C. de Jong

  • Milou G. W. Lentjes

  • Karleen F. Pietersma

  • Wilrike J. Pasman

  • Suzan Wopereis

  • Femke P. M. Hoevenaars

  • July 15, 2026

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  • 1

    Dietary fibers can stimulate endogenous GLP-1 secretion, enhancing satiety and supporting weight management through microbial fermentation.

  • 2

    A scoping review included 49 publications with 52 studies, involving 1,085 participants, primarily focusing on acute interventions.

  • 3

    Dextrins showed robust effects on both GLP-1 secretion and satiety, while other fibers had inconsistent effects on these outcomes.

  • 4

    The evidence is limited by small sample sizes, short interventions, and significant heterogeneity among studies.

  • 5

    Longer-term studies are needed to assess microbiota adaptation and provide robust evidence for dietary fiber's role in GLP-1RA tapering.

Original Source(s)

Dietary fibers to boost endogenous GLP-1 secretion and satiety: a scoping review

  • by Jelle C. B. C. de Jong, Milou G. W. Lentjes, Karleen F. Pietersma, Wilrike J. Pasman, Suzan Wopereis, Femke P. M. Hoevenaars

  • July 15, 2026

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