Serum progesterone levels for ‘rescue’ in hormone replacement FET: a retrospective cohort study of 917 cycles - Takeaways - MDSpire

Serum progesterone levels for ‘rescue’ in hormone replacement FET: a retrospective cohort study of 917 cycles

  • By

  • Goksu Goc

  • Yavuz Emre Sukur

  • June 1, 2026

  • 0 min

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  • 1

    The study analyzed 917 hormone replacement frozen embryo transfer cycles to evaluate the impact of serum progesterone levels on reproductive outcomes.

  • 2

    A single 50 mg intramuscular progesterone rescue was administered to 267 patients with low pre-transfer progesterone levels.

  • 3

    Live birth rates were significantly lower in patients with pre-transfer progesterone levels below 5 ng/mL compared to higher levels.

  • 4

    Miscarriage rates were notably higher in pregnancies with pre-transfer progesterone levels below 5 ng/mL, reaching 46.7%.

  • 5

    The study concluded that pre-transfer progesterone levels below 5 ng/mL are associated with poor prognosis, but further validation is needed.

Original Source(s)

Serum progesterone levels for ‘rescue’ in hormone replacement FET: a retrospective cohort study of 917 cycles

  • by Goksu Goc, Yavuz Emre Sukur

  • June 1, 2026

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