Trends in liver failure-related mortality among middle-aged and older adults with digestive system malignant tumors in the United States, 1999–2023 - Takeaways - MDSpire

Trends in liver failure-related mortality among middle-aged and older adults with digestive system malignant tumors in the United States, 1999–2023

  • By

  • Ling Zhao

  • Jiawei Li

  • Zhengjun Cheng

  • Ao Ren

  • July 13, 2026

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  • 1

    From 1999 to 2023, there were 82,796 liver failure-related deaths among patients aged ≥45 years with digestive system malignant tumors in the U.S.

  • 2

    Annual liver failure-related deaths declined from 4,131 in 1999 to 3,250 in 2023, representing a 21.33% decrease.

  • 3

    The age-adjusted mortality rate decreased from 4.34 to 2.08 per 100,000 population, with an average annual percent change of -2.94%.

  • 4

    Males had consistently higher liver failure-related mortality than females, and deaths increased notably among Hispanic individuals.

  • 5

    Geographic analyses showed significant regional variation in mortality trends, with some areas experiencing slower declines or increases.

Original Source(s)

Trends in liver failure-related mortality among middle-aged and older adults with digestive system malignant tumors in the United States, 1999–2023

  • by Ling Zhao, Jiawei Li, Zhengjun Cheng, Ao Ren

  • July 13, 2026

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