Hysterectomy accelerates sarcopenia risk in US women and mouse models - Takeaways - MDSpire

Hysterectomy accelerates sarcopenia risk in US women and mouse models

  • By

  • Shuquan Wan

  • Cuiping Gong

  • July 14, 2026

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  • 1

    Hysterectomy is associated with an increased risk of sarcopenia in women, with an odds ratio of 1.35 after adjusting for covariates.

  • 2

    The risk of sarcopenia is higher in women who have undergone both hysterectomy and oophorectomy, with an odds ratio of 2.06.

  • 3

    In a senescence-accelerated mouse model, hysterectomy resulted in reduced grip strength, shorter endurance, and decreased muscle fiber size.

  • 4

    Molecular analyses in mice indicated activation of the FOXO1–MuRF-1/Atrogin-1 pathway and changes related to ferroptosis signaling.

  • 5

    The study utilized NHANES data from 2001-2018 and included 6,219 participants to investigate the association between hysterectomy and sarcopenia.

Original Source(s)

Hysterectomy accelerates sarcopenia risk in US women and mouse models

  • by Shuquan Wan, Cuiping Gong

  • July 14, 2026

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