Biochemical and renal-metabolic profiles distinguishing primary aldosteronism from essential hypertension: a systematic review and meta-analysis with implications for endocrine hypertension screening - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Differentiating Primary Aldosteronism from Essential Hypertension: A Systematic Review and Meta-Analysis of Biochemical and Renal-Metabolic Profiles for Endocrine Hypertension Screening

  • By

  • Xuan Zhao

  • Caiyan Zhang

  • Chunxiu Yi

  • Xinyi Liu

  • Shujun Ding

  • Wen Zhang

  • Yajing Zhao

  • September 15, 2026

Share

  • 1

    Primary aldosteronism (PA) is a leading cause of secondary hypertension, affecting 5%-10% of the general hypertensive population.

  • 2

    The systematic review included 74 studies with 26,143 participants, comparing renal-metabolic profiles between PA and essential hypertension (EH).

  • 3

    PA was associated with lower serum potassium, higher sodium, and lower uric acid compared to controls, with significant mean differences observed.

  • 4

    Unilateral/lateralizing PA exhibited lower potassium levels than bilateral PA, indicating distinct biochemical profiles between the subtypes.

  • 5

    The study suggests that renal evaluation for PA should include urinary albumin-to-creatinine ratio alongside traditional filtration measures.

Original Source(s)

Biochemical and renal-metabolic profiles distinguishing primary aldosteronism from essential hypertension: a systematic review and meta-analysis with implications for endocrine hypertension screening

  • by Xuan Zhao, Caiyan Zhang, Chunxiu Yi, Xinyi Liu, Shujun Ding, Wen Zhang, Yajing Zhao

  • September 15, 2026

Related Content

Incidence and baseline predictors of discontinuation in DRCRnet studies

NIH launches $21 million initiative to improve understanding of sex-specific hormonal biology

  • September 14, 2026

Safety and tolerability of intranasal insulin in Parkinson’s disease